TY - JOUR T1 - Establishment of Drug-resistant Cell Lines as a Model in Experimental Oncology: A Review JF - Anticancer Research JO - Anticancer Res SP - 6443 LP - 6455 DO - 10.21873/anticanres.13858 VL - 39 IS - 12 AU - MÁRCIA VANESSA SALES AMARAL AU - ADRHYANN JULLYANNE DE SOUSA PORTILHO AU - EMERSON LUCENA DA SILVA AU - LÍVIA DE OLIVEIRA SALES AU - JERSEY HEITOR DA SILVA MAUÉS AU - MARIA ELISABETE AMARAL DE MORAES AU - CAROLINE AQUINO MOREIRA-NUNES Y1 - 2019/12/01 UR - http://ar.iiarjournals.org/content/39/12/6443.abstract N2 - Many types of cancer are initially susceptible to chemotherapy, but during treatment, patients may develop resistance to therapy. Knowing that acquisition of drug resistance is a major clinical problem in antineoplastic treatment, the present work aimed to present, through a literature review, the development of chemoresistant cells lines as a model in experimental oncology. A total of 110 drug-resistant cell lines, mainly from lung tumors and leukemias, have been developed. In addition, it has been observed that the drugs used for induction of resistance represented the drugs used for first-line treatment of each neoplasia, since the ideal chemotherapeutic treatment to induce resistance in vitro aims at a better modulation of the therapeutic response in order to better study the mechanisms of resistance. ER -