TY - JOUR T1 - Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived from 4-Aminoacetophenone Against Melanoma <em>In Vitro</em> JF - Anticancer Research JO - Anticancer Res SP - 6693 LP - 6699 DO - 10.21873/anticanres.13884 VL - 39 IS - 12 AU - LUÍS EDUARDO SARTO AU - ELBA PEREIRA DE GOIS AU - GABRIELA GOMES DE ANDRADE AU - MATEUS SILVEIRA DE ALMEIDA AU - JENNIFER TAVARES JACON FREITAS AU - ANTÔNIO DE SOUZA REIS JÚNIOR AU - LILIAN PEREIRA FRANCO AU - CLAÚDIA TORRES AU - EDUARDO TONON DE ALMEIDA AU - CIBELE MARLI CAÇÃO PAIVA GOUVÊA Y1 - 2019/12/01 UR - http://ar.iiarjournals.org/content/39/12/6693.abstract N2 - Background/Aim: Melanoma represents a big challenge for clinical treatment. Besides being the most aggressive and the deadliest form of skin cancer, it is often refractory to commonly used anticancer drugs. Hence, developing new anti-cancer agents is crucial to improve refractory melanoma treatment. Studies using palladium(II) complexes have reported antitumor effects on cancer cells. In this study, we aimed to determine the cytotoxic effect of three novel synthesized Pd(II) complexes with Schiff bases derived from 4-aminoacetophenone on the MDA-MB-435 melanoma cell line. Materials and Methods: Cells were treated with ligand and Pd(II) complexes. Cell viability, morphology and death induction upon treatment were examined. Results: Novel synthesized Pd(II) complexes led to decreased viability of cells. They also induced morphological alterations and cell death, mainly in the C3 complex. Conclusion: The novel synthesized complexes have a significant cytotoxic effect on cell line MDA-MB-435, especially C3 and can be considered as an antitumor agent for further studies. ER -