TY - JOUR T1 - The Clinicopathological Significance of the CXCR2 Ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 6645 LP - 6652 DO - 10.21873/anticanres.13879 VL - 39 IS - 12 AU - YURIE YAMAMOTO AU - KENJI KURODA AU - TOMOHIRO SERA AU - ATSUSHI SUGIMOTO AU - SHUHEI KUSHIYAMA AU - SADAAKI NISHIMURA AU - SHINGO TOGANO AU - TOMOHISA OKUNO AU - MAMI YOSHII AU - TATSURO TAMURA AU - TAKAHIRO TOYOKAWA AU - HIROAKI TANAKA AU - KAZUYA MUGURUMA AU - MASAICHI OHIRA AU - MASAKAZU YASHIRO Y1 - 2019/12/01 UR - http://ar.iiarjournals.org/content/39/12/6645.abstract N2 - Background/Aim: We have previously reported that chemokine (C-X-C motif) receptor 2 (CXCR2) signaling was associated with the malignant progression of gastric cancer (GC). We thus examined the clinicopathological significance of CXCR2 ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8, in GC. Patients and Methods: The expression of CXCR2 ligands in 590 GC cases was investigated by immunohistochemistry. Results: The expression was as follows: CXCL1, 46.2% (257/557); CXCL2, 20.7% (122/590); CXCL3, 17.1% (101/589); CXCL5/CXCL6, 2.9% (17/589); CXCL7, 36.4% (215/590); and CXCL8 1.7% (10/585) of the cases. High invasion depth was correlated with CXCL1 expression. Lymph node metastasis and peritoneal cytology positivity were correlated with high expression of CXCL1 and CXCL7. The prognoses of the CXCL1-positive patients were significantly poorer than those of the CXCL1-negative patients (p<0.001). Conclusion: Among the CXCR2 ligands, CXCL7 and especially CXCL1, might play an important role in the malignant progression of GC via CXCR2 signaling. ER -