RT Journal Article
SR Electronic
T1 Rebamipide-containing Film Using Chitosan and HPMC for Oral Mucositis Induced by Cancer Chemotherapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6531
OP 6536
DO 10.21873/anticanres.13868
VO 39
IS 12
A1 TAKEUCHI, ISSEI
A1 TOGO, CHIAKI
A1 MAKINO, KIMIKO
YR 2019
UL http://ar.iiarjournals.org/content/39/12/6531.abstract
AB Background/Aim: Oral mucositis is a significant side effect in cancer treatment. In this study, we aimed to develop a rebamipide-containing film using chitosan and hydroxypropyl methylcellulose (HPMC) to efficiently treat oral mucositis. Materials and Methods: A 0.1% (w/v) rebamipide aqueous solution, a 1.4% (w/v) chitosan aqueous solution containing Pluronic® F-127, and a 1.0% (w/v) HPMC aqueous solution were mixed and dried using a square silicon frame to form a film. Cumulative release ratios of rebamipide from sample films were measured in a phosphate buffer (pH 6.8) at 37°C. Results: Chitosan suppressed the release of rebamipide from the film for up to 30 min. HPMC contributed to the sustained release of the film over a relatively long period of time and the maintenance of its shape. Conclusion: The combined use of chitosan and HPMC is suitable as a base material for rebamipide-containing films.