PT  - JOURNAL ARTICLE
AU  - ISSEI TAKEUCHI
AU  - CHIAKI TOGO
AU  - KIMIKO MAKINO
TI  - Rebamipide-containing Film Using Chitosan and HPMC for Oral Mucositis Induced by Cancer Chemotherapy
AID  - 10.21873/anticanres.13868
DP  - 2019 Dec 01
TA  - Anticancer Research
PG  - 6531--6536
VI  - 39
IP  - 12
4099  - http://ar.iiarjournals.org/content/39/12/6531.short
4100  - http://ar.iiarjournals.org/content/39/12/6531.full
SO  - Anticancer Res2019 Dec 01; 39
AB  - Background/Aim: Oral mucositis is a significant side effect in cancer treatment. In this study, we aimed to develop a rebamipide-containing film using chitosan and hydroxypropyl methylcellulose (HPMC) to efficiently treat oral mucositis. Materials and Methods: A 0.1% (w/v) rebamipide aqueous solution, a 1.4% (w/v) chitosan aqueous solution containing Pluronic® F-127, and a 1.0% (w/v) HPMC aqueous solution were mixed and dried using a square silicon frame to form a film. Cumulative release ratios of rebamipide from sample films were measured in a phosphate buffer (pH 6.8) at 37°C. Results: Chitosan suppressed the release of rebamipide from the film for up to 30 min. HPMC contributed to the sustained release of the film over a relatively long period of time and the maintenance of its shape. Conclusion: The combined use of chitosan and HPMC is suitable as a base material for rebamipide-containing films.