TY - JOUR T1 - Effectiveness of Intraoperative Pulmonary Wedge Resection of Tumor Site Before Lobectomy for Early Lung Adenocarcinoma JF - Anticancer Research JO - Anticancer Res SP - 6829 LP - 6834 DO - 10.21873/anticanres.13899 VL - 39 IS - 12 AU - MOTOAKI YASUKAWA AU - NORIYOSHI SAWABATA AU - TAKESHI KAWAGUCHI AU - SHIGEKI TANIGUCHI Y1 - 2019/12/01 UR - http://ar.iiarjournals.org/content/39/12/6829.abstract N2 - Background/Aim: Circulating tumor cells (CTCs) are tumor cells shed from tumor sites and circulate in the peripheral blood. CTCs can be a surrogate biomarker of recurrence and prognosis. Because surgical manipulation could promote CTCs, it is important to reduce CTCs during surgery. This study aimed to evaluate the effectiveness of intraoperative wedge resection of the tumor site before lobectomy. Patients and Methods: A total of 297 resected stage I lung adenocarcinoma patients were retrospectively reviewed. Patients were divided into two groups: Wedge and Non-Wedge. Recurrence-free survival (RFS) curves were plotted using the Kaplan–Meier method. Cox regression analyses were used to evaluate the hazard ratio (HR) with the endpoint RFS. Results: The 5-year RFS rates were 92.9% and 85.5%, in Wedge and Non-Wedge groups, respectively (p=0.006). Wedge resection was an independent factor associated with RFS (HR=0.342, 95%CI=0.141-0.830, p=0.018). Conclusion: Wedge resection before lobectomy for lung adenocarcinoma patients can improve RFS rates. ER -