RT Journal Article
SR Electronic
T1 Prothrombin 3’end Gene Variants in Patients With Sporadic Colon Adenocarcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6067
OP 6071
DO 10.21873/anticanres.13814
VO 39
IS 11
A1 MARIJA CUMBO
A1 BRANKO TOMIC
A1 SOFIJA DUNJIC
A1 TAMARA JOVANOVIC
A1 MAJA GVOZDENOV
A1 IVA PRUNER
A1 GORANA ARALICA
A1 SANJA KAPITANOVIC
A1 TAMARA CACEV
A1 VALENTINA DJORDJEVIC
YR 2019
UL http://ar.iiarjournals.org/content/39/11/6067.abstract
AB Background/Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3’end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3’end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3’end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3’ end gene variants may play a role in colorectal cancer.