TY - JOUR T1 - The Levels of Interferon-gamma Release as a Biomarker for Non-small-cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors JF - Anticancer Research JO - Anticancer Res SP - 6231 LP - 6240 DO - 10.21873/anticanres.13832 VL - 39 IS - 11 AU - TOMONORI HIRASHIMA AU - TOMOHIRO KANAI AU - HIDEKAZU SUZUKI AU - HIROKO YOSHIDA AU - AKANE MATSUSHITA AU - HIROMI KAWASUMI AU - YUMIKO SAMEJIMA AU - YOSHIMI NODA AU - SHINGO NASU AU - AYAKO TANAKA AU - NAOKO MORISHITA AU - SHOJI HASHIMOTO AU - KUNIMITSU KAWAHARA AU - YOSHITAKA TAMURA AU - NORIO OKAMOTO AU - TOSHIO TANAKA Y1 - 2019/11/01 UR - http://ar.iiarjournals.org/content/39/11/6231.abstract N2 - Background/Aim: The present study aimed to prospectively examine the usefulness of interferon-gamma (IFN-γ) release (IGR) as a biomarker in non-small-cell lung cancer patients receiving immune checkpoint inhibitor treatment (ICI-Tx). Patients and Methods: IGR was measured using enzyme-linked immunosorbent assay at four time points: within 14 days before ICI-Tx (T1), and 8±3 (T2), 22±7 (T3), and 43±7 (T4) days after ICI-Tx. Results: Twenty-nine patients were divided into three groups based on IFN-γ levels in the IGR-positive control: Group-1 (n=8) with <10 IU/ml at T1, Group-2 (n=12) with a decrease in IFN-γ levels to <10 IU/ml at T3 and/or T4, and Group-3 (n=9) without changes in IFN-γ levels. Early progression and ICI-induced interstitial pneumonitis were frequently observed in Group-1 and Group-2, respectively. Group-3 exhibited more treatment cycles than the other groups. All three groups showed clear differences in clinical outcomes. Conclusion: IFN-γ levels could be a biomarker for ICI-Tx. ER -