TY - JOUR T1 - Hookwire-guided Sentinel Lymph Node Biopsy Using Contrast-enhanced Ultrasonography Followed by a One-step Nucleic Acid Amplification (OSNA) Assay for Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 6183 LP - 6192 DO - 10.21873/anticanres.13826 VL - 39 IS - 11 AU - TOMOHIRO MIYAKE AU - KENZO SHIMAZU AU - TOMONORI TANEI AU - YASUTO NAOI AU - NAOFUMI KAGARA AU - MASAFUMI SHIMODA AU - SEUNG JIN KIM AU - SHINZABURO NOGUCHI Y1 - 2019/11/01 UR - http://ar.iiarjournals.org/content/39/11/6183.abstract N2 - Aim: To investigate the feasibility of hookwire-guided sentinel lymph node biopsy (SLNB) using contrast-enhanced ultrasonography (CEUS) followed by a one-step nucleic acid amplification (OSNA) assay. Patients and Methods: Clinical T1-2N0M0 breast cancer patients scheduled to undergo SLNB participated in this study. Both Sonazoid® and dye were used as tracers, and the most upstream sentinel lymph node (SLN) at each lymphatic flow detected by CEUS (First-SLN) was sampled under hookwire guidance, a procedure called “Sona-Hook”. Results: In each of the 50 cases, at least one First-SLN was extracted by “Sona-Hook”. All contrast-enhanced SLNs (CE-SLNs) were dye-positive, and the mean number of CE-SLNs sampled per patient was lower than that of dye-positive SLNs (1.48 vs. 1.88, p<0.01). Through OSNA, qualitative assessment of tumor metastasis between First-SLNs and all SLNs completely matched together. Conclusion: “Sona-Hook” for First-SLN followed by an OSNA assay may be a feasible minimally invasive SLNB strategy. ER -