PT  - JOURNAL ARTICLE
AU  - MAXI TREDER
AU  - STEFAN JANSSEN
AU  - STEVEN E. SCHILD
AU  - DIRK RADES
TI  - Results of Tri-Modality Therapy for Rectal Cancer in Elderly Patients
AID  - 10.21873/anticanres.13830
DP  - 2019 Nov 01
TA  - Anticancer Research
PG  - 6217--6222
VI  - 39
IP  - 11
4099  - http://ar.iiarjournals.org/content/39/11/6217.short
4100  - http://ar.iiarjournals.org/content/39/11/6217.full
SO  - Anticancer Res2019 Nov 01; 39
AB  - Background/Aim: Elderly cancer patients are more prevalent and require special attention. This study focused on the outcome of elderly (≥65 years) rectal cancer patients treated with tri-modality therapy. Patients and Methods: A total of 105 patients receiving neoadjuvant radio-chemotherapy and resection for locally advanced rectal cancers were retrospectively evaluated. Nine characteristics were analyzed for loco-regional control (LRC), metastases-free survival (MFS) and overall survival (OS) including tumor location, gender, age, performance status, radiotherapy technique, primary tumor/lymph node categories, downstaging and histological grading. Results: The 5-year rates of LRC, MFS and OS were 91%, 78% and 87%, respectively. Radio-chemotherapy was not completed in 12 patients (11%) due to toxicity; 18 patients (17%) experienced grade 3 toxicities. A total of 29 patients (28%) had surgical complications. On multivariate analyses, MFS was significantly associated with downstaging (p=0.003) and OS with lower histological grade (p=0.013). Conclusion: Tri-modality therapy resulted in promising outcomes and was tolerated reasonably well by elderly patients. Prognostic factors were identified that may help personalize future treatment.