RT Journal Article SR Electronic T1 G3BP1 Depletion Increases Radiosensitisation by Inducing Oxidative Stress in Response to DNA Damage JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6087 OP 6095 DO 10.21873/anticanres.13816 VO 39 IS 11 A1 EUGENE CHO A1 THOA THI THAN A1 SU-HYEON KIM A1 EUN-RAN PARK A1 MI-YEON KIM A1 KEE HO LEE A1 HYUN JIN SHIN YR 2019 UL http://ar.iiarjournals.org/content/39/11/6087.abstract AB Background: RAS GTPase-activating protein-binding protein (G3BP1) is an RNA-binding protein that is essential for assembling stress granules. Many functions related to the survival and progression of cancer have been reported. The current study aimed to investigate the role of G3BP1 in radio-sensitisation of cancer cells. Materials and Methods: Radiation sensitivity and chemosensitivity were analysed in A549 and H460 cells transfected with G3BP1 siRNAs, and N-acetyl-L-cysteine (NAC) was used to elucidate the involvement of reactive oxygen species (ROS). Results: G3BP1 depletion sensitised lung cancer cell lines to radiation, and the effect was related to ROS. G3BP1 depletion impaired the intracellular ROS scavenging system and NAC abolished the radiation-sensitive phenotypes caused by G3BP1 depletion. Conclusion: The study suggested G3BP1 as a promising target for radio- and chemosensitisation of lung cancer.