RT Journal Article SR Electronic T1 The Impact of Immunonutritional and Physical Status on Surgical Outcome After Pancreaticoduodenectomy in Elderly Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6347 OP 6353 DO 10.21873/anticanres.13846 VO 39 IS 11 A1 KEISHI SUGIMACHI A1 TOMOHIRO IGUCHI A1 YOHEI MANO A1 TOMOHIRO NISHIJIMA A1 TOMONORI NAKANOKO A1 HIDEO UEHARA A1 MASAHIKO SUGIYAMA A1 MITSUHIKO OHTA A1 MASAHIKO IKEBE A1 MASARU MORITA A1 YASUSHI TOH YR 2019 UL http://ar.iiarjournals.org/content/39/11/6347.abstract AB Background/Aim: The aim of this study was to determine the significance of immunonutritional and physical index in the assessment of risk associated with pancreaticoduodenectomy (PD) in the elderly. Patients and Methods: This study enrolled 92 patients who underwent PD. They were divided into 2 groups: Group A included patients 79 years and younger (n=79) and Group B patients 80 years and older (n=13). Among 37 patients, physical function and body composition were also evaluated. Results: Significantly higher neutrophil–lymphocyte ratio, lower prognostic nutritional index (PNI), and controlling nutritional score were observed in Group B. Muscle strength and walking ability were significantly impaired in Group B, although there was no significant difference in body composition. Age was not correlated with the incidence of postoperative complications, overall survival or recurrence-free survival by univariate and multivariate analysis. Conclusion: PD is justified for the elderly, with acceptable morbidity and prognosis. However, immunonutritional status and physical function are significantly impaired; thus, appropriate case selection and active nutritional support are required for the elderly.