TY - JOUR T1 - The Impact of Antibiotics on Prognosis of Metastatic Renal Cell Carcinoma in Japanese Patients Treated With Immune Checkpoint Inhibitors JF - Anticancer Research JO - Anticancer Res SP - 6265 LP - 6271 DO - 10.21873/anticanres.13836 VL - 39 IS - 11 AU - KOSUKE UEDA AU - SATORU YONEKURA AU - NAOYUKI OGASAWARA AU - YOSHIHIRO MATSUNAGA AU - RYUJI HOSHINO AU - HIROFUMI KUROSE AU - KATSUAKI CHIKUI AU - KEIICHIRO UEMURA AU - MAKOTO NAKIRI AU - KIYOAKI NISHIHARA AU - MITSUNORI MATSUO AU - SHIGETAKA SUEKANE AU - TSUKASA IGAWA Y1 - 2019/11/01 UR - http://ar.iiarjournals.org/content/39/11/6265.abstract N2 - Background/Aim: The present study aimed to examine the influence of antibiotics (AB) on the clinical outcomes of Japanese patients treated with immune check point inhibitors (ICIs) for metastatic renal cell carcinoma (RCC) patients. Patients and Methods: A total of 31 patients with metastatic RCC treated with ICIs from November 2016 to April 2019 were retrospectively reviewed and analyzed. Results: Five patients were treated with AB prior to ICIs treatment. Median progression free survival (PFS) of patients treated with AB vs. patients not treated with AB was 2.8 months and 18.4 months, respectively. The difference between PFS was statistically significant (p=0.0004). In multivariate analyses, AB use (p=0.0377) and presence of immune related adverse events (p=0.0042) were independent prognostic factors for PFS in association with ICIs therapy. Conclusion: The use of AB before ICIs treatment was a predictor of poor ICIs response in metastatic RCC. ER -