@article {UEDA6265, author = {KOSUKE UEDA and SATORU YONEKURA and NAOYUKI OGASAWARA and YOSHIHIRO MATSUNAGA and RYUJI HOSHINO and HIROFUMI KUROSE and KATSUAKI CHIKUI and KEIICHIRO UEMURA and MAKOTO NAKIRI and KIYOAKI NISHIHARA and MITSUNORI MATSUO and SHIGETAKA SUEKANE and TSUKASA IGAWA}, title = {The Impact of Antibiotics on Prognosis of Metastatic Renal Cell Carcinoma in Japanese Patients Treated With Immune Checkpoint Inhibitors}, volume = {39}, number = {11}, pages = {6265--6271}, year = {2019}, doi = {10.21873/anticanres.13836}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: The present study aimed to examine the influence of antibiotics (AB) on the clinical outcomes of Japanese patients treated with immune check point inhibitors (ICIs) for metastatic renal cell carcinoma (RCC) patients. Patients and Methods: A total of 31 patients with metastatic RCC treated with ICIs from November 2016 to April 2019 were retrospectively reviewed and analyzed. Results: Five patients were treated with AB prior to ICIs treatment. Median progression free survival (PFS) of patients treated with AB vs. patients not treated with AB was 2.8 months and 18.4 months, respectively. The difference between PFS was statistically significant (p=0.0004). In multivariate analyses, AB use (p=0.0377) and presence of immune related adverse events (p=0.0042) were independent prognostic factors for PFS in association with ICIs therapy. Conclusion: The use of AB before ICIs treatment was a predictor of poor ICIs response in metastatic RCC.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/39/11/6265}, eprint = {https://ar.iiarjournals.org/content/39/11/6265.full.pdf}, journal = {Anticancer Research} }