RT Journal Article SR Electronic T1 The Association of MMP-11 Promoter Polymorphisms With Susceptibility to Lung Cancer in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5375 OP 5380 DO 10.21873/anticanres.13731 VO 39 IS 10 A1 GUAN-LIANG CHEN A1 SHOU-CHENG WANG A1 WEI-CHIEN HUANG A1 WEN-SHIN CHANG A1 CHIA-WEN TSAI A1 HSIN-TING LI A1 TE-CHUN SHEN A1 TE-CHUN HSIA A1 DA-TIAN BAU YR 2019 UL http://ar.iiarjournals.org/content/39/10/5375.abstract AB Background/Aim: Matrix metalloproteinases-11 (MMP-11) overexpression has been reported in various types of cancer including lung cancer. We aimed to examine the contribution of MMP-11 genotypes to lung cancer risk. Materials and Methods: In this case-control study, the MMP-11 rs738791, rs2267029, rs738792 and rs28382575 genotypes were determined among 358 lung cancer patients and 716 age- and gender-matched healthy control Taiwanese. Results: The percentages of rs738791 CT and TT were 50.6% and 9.2% in the case group, slightly higher than 48.5% and 8.1% in the control group (p for trend=0.5638). The allelic analysis showed that the rs738791 T allele did not confer lung cancer risk compared with the C allele. Similarly, there was no association between rs2267029, rs738792 or rs28382575 and lung cancer risk. There was no joint effect of MMP-11 genotypes among ever smokers or non-smokers. Conclusion: The genotypes of MMP-11 play a minor role in determining lung cancer risk in Taiwan.