PT  - JOURNAL ARTICLE
AU  - GUAN-LIANG CHEN
AU  - SHOU-CHENG WANG
AU  - WEI-CHIEN HUANG
AU  - WEN-SHIN CHANG
AU  - CHIA-WEN TSAI
AU  - HSIN-TING LI
AU  - TE-CHUN SHEN
AU  - TE-CHUN HSIA
AU  - DA-TIAN BAU
TI  - The Association of <em>MMP-11</em> Promoter Polymorphisms With Susceptibility to Lung Cancer in Taiwan
AID  - 10.21873/anticanres.13731
DP  - 2019 Oct 01
TA  - Anticancer Research
PG  - 5375--5380
VI  - 39
IP  - 10
4099  - http://ar.iiarjournals.org/content/39/10/5375.short
4100  - http://ar.iiarjournals.org/content/39/10/5375.full
SO  - Anticancer Res2019 Oct 01; 39
AB  - Background/Aim: Matrix metalloproteinases-11 (MMP-11) overexpression has been reported in various types of cancer including lung cancer. We aimed to examine the contribution of MMP-11 genotypes to lung cancer risk. Materials and Methods: In this case-control study, the MMP-11 rs738791, rs2267029, rs738792 and rs28382575 genotypes were determined among 358 lung cancer patients and 716 age- and gender-matched healthy control Taiwanese. Results: The percentages of rs738791 CT and TT were 50.6% and 9.2% in the case group, slightly higher than 48.5% and 8.1% in the control group (p for trend=0.5638). The allelic analysis showed that the rs738791 T allele did not confer lung cancer risk compared with the C allele. Similarly, there was no association between rs2267029, rs738792 or rs28382575 and lung cancer risk. There was no joint effect of MMP-11 genotypes among ever smokers or non-smokers. Conclusion: The genotypes of MMP-11 play a minor role in determining lung cancer risk in Taiwan.