RT Journal Article
SR Electronic
T1 Diagnostic Accuracy of CYFRA21-1 in the Differential Diagnosis of Pleural Effusions
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5071
OP 5076
DO 10.21873/anticanres.13700
VO 39
IS 9
A1 TRAPÉ, JAUME
A1 SANT, FRANCESC
A1 MONTESINOS, JESUS
A1 ARNAU, ANNA
A1 SALA, MARIA
A1 BERNADICH, OSCAR
A1 MARTÍN, ESPERANZA
A1 PERICH, DAMIA
A1 LOPEZ, JOAN
A1 ROS, SANDRA
A1 ESTEVE-VALVERDE, ENRIQUE
A1 PÉREZ, RAFAEL
A1 GONZÁLEZ-FERNÁNDEZ, CAROLINA
A1 ALIGUE, JORDI
A1 CATOT, SILVIA
A1 DOMENECH, MONTSERRAT
A1 RUIZ, DOMINGO
A1 BONET, MARIONA
A1 MOLINA, RAFAEL
A1 ORDEIG, JOSEP
YR 2019
UL http://ar.iiarjournals.org/content/39/9/5071.abstract
AB Background/Aim: Approximately 20% of pleural effusions are associated with cancer; about 50% require invasive procedures to perform diagnosis. Determination of the concentration of soluble cytokeratin 19-fragments (CYFRA21-1) may help identify patients with malignant effusions. However, pathologies other than cancer can increase its concentration. The identification of these possible false positives with routine tests CRP, ADA, % polymorphonuclear cells (PN) may improve diagnostic accuracy. This study aimed to determine the diagnostic accuracy of CYFRA21-1 in the detection of malignant pleural effusions and the possible false positives. Materials and Methods: Analysis of CYFRA21-1, adenosine deaminase (ADA), C-reactive protein (CRP), and the percentage of polymorphonuclear leukocytes (PN%) in the fluid from 643 consecutive undiagnosed pleural effusions was performed. Results: CYFRA21-1 showed 38.7% sensitivity and 97.3% specificity at 175 ng/ml cut-off. Effusions not suspicious of a false-positive showed 39.0% sensitivity and 98.2% specificity, while effusions suspicious of false positive showed lower sensitivity (36.4%) and specificity (95.0%). Conclusion: The diagnostic accuracy of CYFRA21-1 in pleural effusions can be improved by classification according to the possibility of false positives.