PT - JOURNAL ARTICLE AU - CARLO SIGNORELLI AU - MARIO GIOVANNI CHILELLI AU - ISABELLA SPERDUTI AU - SILVANA GIACINTI AU - PIETRO MARIA AMODIO AU - RAFFAELE MACARONE PALMIERI AU - TERESA VALENTINA RANALLI AU - VITO VINCENZO GOMES AU - MARIA ELENA ROSETTO AU - FABRIZIO NELLI AU - ENZO MARIA RUGGERI TI - Correlation of Tumor Location to Clinical Outcomes in Colorectal Cancer: A Single-institution Retrospective Analysis AID - 10.21873/anticanres.13679 DP - 2019 Sep 01 TA - Anticancer Research PG - 4917--4924 VI - 39 IP - 9 4099 - http://ar.iiarjournals.org/content/39/9/4917.short 4100 - http://ar.iiarjournals.org/content/39/9/4917.full SO - Anticancer Res2019 Sep 01; 39 AB - Background/Aim: Recent data highlighted that location of metastatic colorectal cancer (mCRC) may have a prognostic impact and also a predictive value of the outcomes of first-line therapy. Materials and Methods: The records of mCRC patients who underwent first-line therapy from 2011 to April 2018 at our Institute were retrospectively reviewed. Progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) according to the primary tumor location were investigated. Results: Overall, 130 patients were eligible. Two-year OS was 82.9% in left-sided colon cancers (LCC) and 67.5% in right-sided (RCC) (p=0.32). One-year mPFS was statistically longer in LCC (46.8% vs. 24.2%, p=0.0005). mPFS was longer in LCC treated with anti-VEGF vs. anti-EGFR (p=0.06). ORR was 51.1% in LCC, 25% in RCC (p=0.008). Overall, 11 complete responses all in LCC were observed (p=0.03). Conclusion: Tumor location has a prognostic impact and might influence the outcomes of mCRC patients.