TY - JOUR T1 - Therapeutic Outcome of >10 Cycles of Cabazitaxel for Castration-resistant Prostate Cancer: A Multi-institutional Study JF - Anticancer Research JO - Anticancer Res SP - 4411 LP - 4414 DO - 10.21873/anticanres.13612 VL - 39 IS - 8 AU - MASAKI SHIOTA AU - MOTONOBU NAKAMURA AU - AKIRA YOKOMIZO AU - TOSHIHISA TOMODA AU - NAOTAKA SAKAMOTO AU - NARIHITO SEKI AU - SHUJI HASEGAWA AU - TAKAKAZU YUNOKI AU - MASAHIKO HARANO AU - KENTARO KUROIWA AU - MASATOSHI ETO Y1 - 2019/08/01 UR - http://ar.iiarjournals.org/content/39/8/4411.abstract N2 - Background/Aim: Cabazitaxel use has usually been limited to up to 10 cycles in most countries according to the protocol in the TROPIC trial. Therefore, clinical data on cabazitaxel use beyond 10 cycles is limited. The aim of this study was to report the therapeutic outcome of cabazitaxel chemotherapy administered for >10 cycles. Patients and Methods: This study included 74 Japanese patients with prostate cancer between 2014 and 2017. Patients background, and treatment outcomes including PSA decline, progression-free survival, treatment-failure-free survival, overall survival, and adverse events were investigated, comparing patients treated with ≤10 and >10 cycles. Results: Patients characteristics were favorable as indicated by the higher number of cycles of prior docetaxel chemotherapy, absence of pain, and absence of bony and visceral metastases among men who received >10 cycles of cabazitaxel. PSA response, progression-free survival, treatment-failure-free survival and overall survival were better among patients treated with >10 cycles of cabazitaxel compared to those treated with ≤10 cycles. The incidence of severe adverse events was similar between the two groups. Conclusion: Taken together, this study suggested that continuous chemotherapy with cabazitaxel beyond 10 cycles may be beneficial. ER -