PT  - JOURNAL ARTICLE
AU  - MARIA LETIZIA CONSOLI
AU  - ALESSANDRA ROMANO
AU  - NUNZIATINA LAURA PARRINELLO
AU  - LOREDANA TAMBÈ
AU  - MARIA ANNA ROMEO
AU  - DOMENICO SALEMI
AU  - ALESSANDRA SANTORO
AU  - FRANCESCO DI RAIMONDO
TI  - Unusual Karyotype in Acute Myelomonocitic Leukemia: A Case Report
AID  - 10.21873/anticanres.13599
DP  - 2019 Aug 01
TA  - Anticancer Research
PG  - 4329--4332
VI  - 39
IP  - 8
4099  - http://ar.iiarjournals.org/content/39/8/4329.short
4100  - http://ar.iiarjournals.org/content/39/8/4329.full
SO  - Anticancer Res2019 Aug 01; 39
AB  - Background/Aim: Acute myeloid leukemia is well characterized by chromosomal aberrations that correspond to various subtypes of acute leukemias. The t(8;21)(q22;q22) is a frequent chromosomal abnormality strongly associated with acute myeloblastic leukemia with maturation (AML-M2), but is rarely associated with other subtypes. Translocation involving a third chromosome could produce new genetic rearrangements that lead to leukemogenesis. Patients and Methods: Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) were performed to identify the karyotype. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the AML1/ETO transcript. Results/Conclusion: We herein report a novel rearrangement with a three-way translocation involving chromosomes 8, 21 and another unknown chromosome, in an 83-year-old female patient diagnosed as AML-M4, with an ALM1/ETO negative transcript. This is an uncommon case of AML-M4 with three-way translocation in a new variant of t(8;21) acute myeloid leukaemia. The detailed mechanism of different phenotype expression is unclear. Further study is needed to identify the leukemogenetic transformation resulting from t(8;21) translocation.