RT Journal Article
SR Electronic
T1 Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4485
OP 4490
DO 10.21873/anticanres.13623
VO 39
IS 8
A1 MASANORI AKASHI
A1 TORU HISAKA
A1 HISAMUNE SAKAI
A1 HIROTO ISHIKAWA
A1 RYUICHI KAWAHARA
A1 YUICHI GOTO
A1 YORIKO NOMURA
A1 MASAFUMI YASUNAGA
A1 FUMIHIKO FUJITA
A1 MASAHIKO TANIGAWA
A1 YOSHIKI NAITO
A1 JUN AKIBA
A1 HIROHISA YANO
A1 HIROYUKI TANAKA
A1 YOSHITO AKAGI
A1 KOJI OKUDA
YR 2019
UL http://ar.iiarjournals.org/content/39/8/4485.abstract
AB Background/Aim: Intraductal papillary mucinous neoplasm (IPMN) has a variety of histological and morphological appearances. Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. The aim of this study was to elucidate the molecular basis of IPMN variation in different types of lesions. Materials and Methods: The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. The MMP score was calculated as the sum of the score of staining distribution and the score of the intensity staining. Results: MMP scores were correlated with histological grade, histological subtype, and type of invasion. MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups. Conclusion: MMP expression varied between different types of IPMN, a result supporting differences in molecular basis of malignancies. These considerations may be helpful for optimal management or treatment according to various types of IPMN.