PT - JOURNAL ARTICLE AU - MASANORI AKASHI AU - TORU HISAKA AU - HISAMUNE SAKAI AU - HIROTO ISHIKAWA AU - RYUICHI KAWAHARA AU - YUICHI GOTO AU - YORIKO NOMURA AU - MASAFUMI YASUNAGA AU - FUMIHIKO FUJITA AU - MASAHIKO TANIGAWA AU - YOSHIKI NAITO AU - JUN AKIBA AU - HIROHISA YANO AU - HIROYUKI TANAKA AU - YOSHITO AKAGI AU - KOJI OKUDA TI - Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas AID - 10.21873/anticanres.13623 DP - 2019 Aug 01 TA - Anticancer Research PG - 4485--4490 VI - 39 IP - 8 4099 - http://ar.iiarjournals.org/content/39/8/4485.short 4100 - http://ar.iiarjournals.org/content/39/8/4485.full SO - Anticancer Res2019 Aug 01; 39 AB - Background/Aim: Intraductal papillary mucinous neoplasm (IPMN) has a variety of histological and morphological appearances. Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. The aim of this study was to elucidate the molecular basis of IPMN variation in different types of lesions. Materials and Methods: The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. The MMP score was calculated as the sum of the score of staining distribution and the score of the intensity staining. Results: MMP scores were correlated with histological grade, histological subtype, and type of invasion. MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups. Conclusion: MMP expression varied between different types of IPMN, a result supporting differences in molecular basis of malignancies. These considerations may be helpful for optimal management or treatment according to various types of IPMN.