PT  - JOURNAL ARTICLE
AU  - VIRGINIA VALENTINI
AU  - VERONICA ZELLI
AU  - EMANUELA GAGGIANO
AU  - VALENTINA SILVESTRI
AU  - PIERA RIZZOLO
AU  - AGOSTINO BUCALO
AU  - STEFANO CALVIERI
AU  - SARA GRASSI
AU  - PASQUALE FRASCIONE
AU  - PIETRO DONATI
AU  - GIUSEPPE SODA
AU  - LAURA OTTINI
AU  - ANTONIO GIOVANNI RICHETTA
TI  - MiRNAs as Potential Prognostic Biomarkers for Metastasis in Thin and Thick Primary Cutaneous Melanomas
AID  - 10.21873/anticanres.13566
DP  - 2019 Aug 01
TA  - Anticancer Research
PG  - 4085--4093
VI  - 39
IP  - 8
4099  - http://ar.iiarjournals.org/content/39/8/4085.short
4100  - http://ar.iiarjournals.org/content/39/8/4085.full
SO  - Anticancer Res2019 Aug 01; 39
AB  - Background/Aim: The identification of novel prognostic biomarkers for melanoma metastasis is essential to improve patient outcomes. To this aim, we characterized miRNA expression profiles in relation to metastasis in melanoma and correlated miRNAs expression with clinical-pathological factors. Materials and Methods: MiR-145-5p, miR-150-5p, miR-182-5p, miR-203-3p, miR-205-5p and miR-211-5p expression levels were analyzed in primary cutaneous melanomas, including thin and thick melanomas, and in melanoma metastases by quantitative Real-Time PCR. Results: A significantly lower miR-205-5p expression was found in metastases compared to primary melanomas. Furthermore, a progressive down-regulation of miR-205-5p expression was observed from loco-regional to distant metastasis. Significantly lower miR-145-5p and miR-203-3p expression levels were found in cases with Breslow thickness >1 mm, high Clark level, ulceration and mitotic rate ≥1/mm2. Conclusion: Our findings point to miR-205-5p as potential biomarker of distant metastases and to miR-145-5p and miR-203-3p as markers of aggressiveness in melanoma.