TY - JOUR T1 - Clinical and Prognostic Significance of Neoplastic Spindle Cells in Gallbladder Cancer JF - Anticancer Research JO - Anticancer Res SP - 4561 LP - 4568 DO - 10.21873/anticanres.13634 VL - 39 IS - 8 AU - RYUTA MIDORIKAWA AU - TORU HISAKA AU - HISAMUNE SAKAI AU - YORIKO NOMURA AU - YUICHI GOTO AU - TOSHIHIRO SATO AU - RYUICHI KAWAHARA AU - HIROTO ISHIKAWA AU - FUMIHIKO FUJITA AU - MASAFUMI YASUNAGA AU - MASAHIKO TANIGAWA AU - YOSHIKI NAITO AU - JUN AKIBA AU - HIROHISA YANO AU - HIROYUKI TANAKA AU - YOSHITO AKAGI AU - KOJI OKUDA Y1 - 2019/08/01 UR - http://ar.iiarjournals.org/content/39/8/4561.abstract N2 - Background/Aim: Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. Materials and Methods: Specimens were obtained from 62 patients with gallbladder cancer who underwent surgery. The emergence of NSCs and their correlation with clinicopathological factors, prognosis, and EMT markers was evaluated. Results: The NSC grade correlated with tumor size, preoperative CA19-9, surgical margin, the degree of differentiation, the depth of invasion, lymph node metastasis, lymphatic invasion, vascular invasion, and perineural invasion. Multivariate analysis of overall survival showed that NSCs were an independent prognostic factor. A correlation between NSCs and EMT was also suggested. Conclusion: NSCs are an independent prognostic factor for patients with postoperative gallbladder cancer, which also suggests a correlation between NSCs and EMT. ER -