PT  - JOURNAL ARTICLE
AU  - DOUG DIX
TI  - Human Carcinogenesis: The Role of Age and Gender
AID  - 10.21873/anticanres.13608
DP  - 2019 Aug 01
TA  - Anticancer Research
PG  - 4385--4391
VI  - 39
IP  - 8
4099  - http://ar.iiarjournals.org/content/39/8/4385.short
4100  - http://ar.iiarjournals.org/content/39/8/4385.full
SO  - Anticancer Res2019 Aug 01; 39
AB  - Background/Aim: To identify the reason for age and gender differences in cancer risk. Patients and Methods: Age-standardized incidence rates for 17 cancer types were compared between genders in 50 populations. For each cancer type, the female/male rate ratio was listed in fixed order of population. Correlation coefficients were calculated between these lists in all pairwise combinations. For each population, the female/male rate ratio was listed in fixed order of cancer. Correlation coefficients were calculated between lists in all pairwise combinations. Results: Only four pairwise combinations for cancer type gave a correlation coefficient greater than 0.700. For each population, the lowest correlation coefficient was 0.950. Conclusion: The reason for the differences in risk of cancer varies with each type of cancer, but remains fixed in all populations. It is suspected that species-specific genes control stem cell telomere dynamics in a fixed strategy at rates that vary among tissues and between genders.