RT Journal Article SR Electronic T1 Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4503 OP 4509 DO 10.21873/anticanres.13626 VO 39 IS 8 A1 ZHANG, RAN A1 INAGAWA, HIROYUKI A1 UCHIBORI, SACHIKO A1 MASAKI, TSUTOMU A1 KOBARA, HIDEKI A1 SOMA, GEN-ICHIRO YR 2019 UL http://ar.iiarjournals.org/content/39/8/4503.abstract AB Background/Aim: Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases. Materials and Methods: Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed. Results: SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading. Conclusion: Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.