PT  - JOURNAL ARTICLE
AU  - ZHANG, RAN
AU  - INAGAWA, HIROYUKI
AU  - UCHIBORI, SACHIKO
AU  - MASAKI, TSUTOMU
AU  - KOBARA, HIDEKI
AU  - SOMA, GEN-ICHIRO
TI  - Preventive Effect of Oral Administration of <em>Pantoea agglomerans</em>-derived LPS in a Hypertensive Rat Model Upon Salt Loading
AID  - 10.21873/anticanres.13626
DP  - 2019 Aug 01
TA  - Anticancer Research
PG  - 4503--4509
VI  - 39
IP  - 8
4099  - http://ar.iiarjournals.org/content/39/8/4503.short
4100  - http://ar.iiarjournals.org/content/39/8/4503.full
SO  - Anticancer Res2019 Aug 01; 39
AB  - Background/Aim: Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases. Materials and Methods: Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed. Results: SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading. Conclusion: Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.