<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">ZHANG, RAN</style></author><author><style face="normal" font="default" size="100%">INAGAWA, HIROYUKI</style></author><author><style face="normal" font="default" size="100%">UCHIBORI, SACHIKO</style></author><author><style face="normal" font="default" size="100%">MASAKI, TSUTOMU</style></author><author><style face="normal" font="default" size="100%">KOBARA, HIDEKI</style></author><author><style face="normal" font="default" size="100%">SOMA, GEN-ICHIRO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Preventive Effect of Oral Administration of &lt;em&gt;Pantoea agglomerans&lt;/em&gt;-derived LPS in a Hypertensive Rat Model Upon Salt Loading</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4503-4509</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.13626</style></doi><volume><style face="normal" font="default" size="100%">39</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases. Materials and Methods: Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed. Results: SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading. Conclusion: Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.</style></abstract></record></records></xml>