TY - JOUR T1 - Novel Therapeutic Approaches for Epstein-Barr Virus Associated Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 4003 LP - 4010 DO - 10.21873/anticanres.13555 VL - 39 IS - 8 AU - BYUNG WOOG KANG AU - DONG WON BAEK AU - HYOJEUNG KANG AU - JIN HO BAEK AU - JONG GWANG KIM Y1 - 2019/08/01 UR - http://ar.iiarjournals.org/content/39/8/4003.abstract N2 - Epstein-Barr virus (EBV)-associated gastric cancer (GC) (EBVaGC) is classified as one of four GC subtypes by comprehensive molecular characterization. Though the mechanism of tumorigenesis by EBV infection has not yet been fully clarified, EBV infection might contribute to the malignant transformation of GC cells by involving various cellular processes and signaling pathways. EBVaGC has shown the following distinct characteristics in contrast to other subtypes: extreme DNA hypermethylation, recurrent phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) mutations, overexpression of programmed cell death ligand 1/2 (PD-L1/2), and occasional immune cell signaling activation. Therefore, using these molecular features as guides, targeted agents need to be evaluated in clinical trials for EBVaGC. Accordingly, this review uses the best available evidence to focus on novel therapeutic approaches using the distinct pathologic characteristics of EBVaGC patients. ER -