TY - JOUR T1 - Risk Factors Associated With Early Recurrence of Borderline Resectable Pancreatic Ductal Adenocarcinoma After Neoadjuvant Chemoradiation Therapy and Curative Resection JF - Anticancer Research JO - Anticancer Res SP - 4431 LP - 4440 DO - 10.21873/anticanres.13615 VL - 39 IS - 8 AU - NOBUHIRO TSUCHIYA AU - RYUSEI MATSUYAMA AU - TAKASHI MURAKAMI AU - YASUHIRO YABUSHITA AU - YU SAWADA AU - TAKAFUMI KUMAMOTO AU - ITARU ENDO Y1 - 2019/08/01 UR - http://ar.iiarjournals.org/content/39/8/4431.abstract N2 - Background/Aim: To identify risk factors of early recurrence after neoadjuvant chemoradiation therapy (NACRT) and curative pancreatectomy in patients with borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: Sixty-one patients with BR-PDAC who underwent curative resection after NACRT during July 2009-June 2014 were included. Patients were divided into early recurrence (i.e., developed recurrence within 1 year after pancreatectomy; n=30) and late/non-recurrence groups (n=31). The patient characteristics, clinicopathological factors of early recurrence, and survival time were retrospectively compared between groups. Results: In the univariate analysis, the maximum standardized uptake value (SUVmax), microvascular invasion, and lymph node metastasis were associated with early recurrence. In the multivariate analysis, the pre-NACRT SUVmax and microvascular invasion in the early recurrence group were significantly different from that in the late/non-recurrence group. A pre-NACRT SUVmax >4.1 was an independent predictor of poor recurrence-free and overall survival. Conclusion: SUVmax and microvascular invasion are independent predictors of poor recurrence-free and overall survival after NACRT for BR-PDAC. Although complete pancreatectomy after NACRT was performed, approximately half of the patients had recurrence within 1 year. ER -