RT Journal Article
SR Electronic
T1 Is Concurrent Chemotherapy With Radiotherapy for Esophageal Cancer Beneficial in Patients Aged 80 Years or Older?
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4279
OP 4283
DO 10.21873/anticanres.13592
VO 39
IS 8
A1 KEIICHI JINGU
A1 NORIYOSHI TAKAHASHI
A1 YUJI MURAKAMI
A1 KAZUKI ISHIKAWA
A1 SATOSHI ITASAKA
A1 TAKEO TAKAHASHI
A1 FUMIAKI ISOHASHI
A1 TORU SAKAYAUCHI
A1 KAZUHIKO OGAWA
A1 JROSG Working Subgroup of Gastrointestinal Cancers
YR 2019
UL http://ar.iiarjournals.org/content/39/8/4279.abstract
AB Background/Aim: To determine whether concurrent chemotherapy with radiotherapy should be performed in elderly patients with esophageal cancer. Patients and Methods: A total of 185 patients aged 80 years or older who were treated with definitive radiotherapy alone or combined with chemoradiotherapy for esophageal cancer at seven institutions were enrolled. In order to compare survival rates of patients treated with chemoradiotherapy with those of patients treated with radiotherapy alone, propensity score matching was performed to homogenize the two populations. Results: For the whole patient cohort, the 3-year overall survival (OS) rate was 52.6% and the median survival was 42.5 months. After propensity score matching, the 3-year OS rate for the chemoradiotherapy group was not significantly better than that for the group treated with radiotherapy alone (53.7% vs. 59.9%, p=0.876). Conclusion: Concurrent chemotherapy with radiotherapy for esophageal cancer in patients aged 80 years or older did not have significant OS benefit over radiotherapy alone.