RT Journal Article
SR Electronic
T1 Sinusoidal Obstruction Syndrome and Postoperative Complications Resulting from Preoperative Chemotherapy for Colorectal Cancer Liver Metastasis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4549
OP 4554
DO 10.21873/anticanres.13632
VO 39
IS 8
A1 HISAKA, TORU
A1 ISHIKAWA, HIROTO
A1 SAKAI, HISAMUNE
A1 KAWAHARA, RYUICHI
A1 GOTO, YUICHI
A1 NOMURA, YORIKO
A1 YASUNAGA, MASAFUMI
A1 KINUGASA, TETSUSHI
A1 FUJITA, FUMIHIKO
A1 MIZOBE, TOMOAKI
A1 FUKAHORI, MASARU
A1 MIWA, KEISUKE
A1 NAKASHIMA, OSAMU
A1 TANIGAWA, MASAHIKO
A1 NAITO, YOSHIKI
A1 AKIBA, JUN
A1 YANO, HIROHISA
A1 TANAKA, HIROYUKI
A1 AKAGI, YOSHITO
A1 OKUDA, KOJI
YR 2019
UL http://ar.iiarjournals.org/content/39/8/4549.abstract
AB Background/Aim: The aim of this study was to investigate the effects of preoperative chemotherapy on the healthy, metastasis-free part of the liver in colorectal cancer patients with liver metastasis, and the relationship between chemotherapy and postoperative complications. Patients and Methods: Our study included 90 cases of colorectal cancer liver metastasis resected after preoperative chemotherapy. The patients were divided into three groups according to the received chemotherapy regimen: 20 cases received mFOLFOX6, 54 cases a combination of mFOLFOX6 with bevacizumab, and 16 cases a combination of mFOLFOX6 and cetuximab or panitumumab. Results: The mean numbers of sinusoidal injuries for each chemotherapy type were compared. The group treated with the combination of mFOLFOX6 and bevacizumab showed a lower extent of sinusoidal injury relative to other groups; this intergroup difference became increasingly remarkable as the number of chemotherapy cycles increased. Complications of various extents were found in all three groups, but no significant differences were observed between the three groups. Conclusion: In cases where preoperative chemotherapy was extended over a long period, combined use of bevacizumab was thought to be effective because of stabilization of disturbed liver hemodynamics resulting from sinusoidal injury suppression effects, allowing effective distribution of anti-cancer agents to tumors.