RT Journal Article
SR Electronic
T1 CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5437
OP 5442
VO 36
IS 10
A1 ALEN BIŠĆANIN
A1 NEVEN LJUBIČIĆ
A1 MARKO BOBAN
A1 DRINKO BALIČEVIĆ
A1 IVANA PAVIĆ
A1 MIRELA MAVER BIŠĆANIN
A1 IVAN BUDIMIR
A1 ZDRAVKO DOROSULIC
A1 MARKO DUVNJAK
YR 2016
UL http://ar.iiarjournals.org/content/36/10/5437.abstract
AB Background/Aim: Colorectal cancer is a major public health problem. The adenoma–carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. Patients and Methods: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. Results: CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). Conclusion: CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.