PT  - JOURNAL ARTICLE
AU  - ALEN BIŠĆANIN
AU  - NEVEN LJUBIČIĆ
AU  - MARKO BOBAN
AU  - DRINKO BALIČEVIĆ
AU  - IVANA PAVIĆ
AU  - MIRELA MAVER BIŠĆANIN
AU  - IVAN BUDIMIR
AU  - ZDRAVKO DOROSULIC
AU  - MARKO DUVNJAK
TI  - CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential
DP  - 2016 Oct 01
TA  - Anticancer Research
PG  - 5437--5442
VI  - 36
IP  - 10
4099  - http://ar.iiarjournals.org/content/36/10/5437.short
4100  - http://ar.iiarjournals.org/content/36/10/5437.full
SO  - Anticancer Res2016 Oct 01; 36
AB  - Background/Aim: Colorectal cancer is a major public health problem. The adenoma–carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. Patients and Methods: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. Results: CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). Conclusion: CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.