RT Journal Article
SR Electronic
T1 Heterogeneity of Primary Site Biopsies in Head and Neck Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 665
OP 669
VO 31
IS 2
A1 MOERTEL, SUSANNE
A1 ACKERMANN, HANNS
A1 BAGHI, MEHRAN
A1 ECKARDT, ANNE
A1 WAGENBLAST, JENS
A1 STÖVER, TIMO
A1 HAMBEK, MARKUS
YR 2011
UL http://ar.iiarjournals.org/content/31/2/665.abstract
AB Aim: There is no common standard defining how biopsies for translational research purposes should be performed. In our study, the impact of two different biopsy methods on the results of immunohistochemical staining of the samples for epidermal growth factor receptor (EGFR) and the proliferation antigen Ki-67 were evaluated. Patients and Methods: Twenty-four patients who underwent surgical treatment of their HNSCC tumour were included. From each surgically resected tumour, one superficial biopsy and one core-needle biopsy through the cross-section of the tumour were taken. As a positive control, a tissue slide through the primary tumour was made. Results: The analysis showed that neither the superficial nor the core biopsy expression of EGFR correlated significantly with that of the tumour. The analysis showed that the superficial biopsy expression of Ki-67 correlated significantly with that of tumour. Conclusion: Translational research projects based on biopsy tissues should be using whole surgical resection specimens of a tumour.