RT Journal Article
SR Electronic
T1 Prediction of Response in Cancer Immunotherapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 639
OP 647
VO 31
IS 2
A1 CHARACIEJUS, DAINIUS
A1 JACOBS, JOHN J.L.
A1 PAŠUKONIENĖ, VITA
A1 KAZLAUSKAITĖ, NIJOLĖ
A1 DANILEVIČIŪTĖ, VITA
A1 MAURICAS, MYKOLAS
A1 DEN OTTER, WILLEM
YR 2011
UL http://ar.iiarjournals.org/content/31/2/639.abstract
AB This review focuses on the relationship between pre-treatment immune parameter values and outcome of immunotherapy of cancer patients. The evidence presented in this review suggests that there is a relationship between pre-treatment immune parameter values and survival of cancer patients treated with immunotherapy. Tumour-infiltrating immune cells may have a predictive value for immunotherapy, but predictive power might be obtained from peripheral blood leukocytes. Use of peripheral blood may be preferable due to the convenience of collection and analysis compared to using tumour-infiltrating cells. In vivo numbers of cells of the immune system correlate better with clinical outcome than their functional activity ex vivo. This suggests that immunological antitumour mechanisms in vivo are not always related to generally accepted functional parameters of lymphocytes, such as cytotoxicity or cytokine production, ex vivo. The proliferative status of CD8+ T lymphocytes seems promising for prediction of response in cancer immunotherapy.