PT  - JOURNAL ARTICLE
AU  - WEISSENBACHER, TOBIAS
AU  - KUHN, CHRISTINA
AU  - MAYR, DORIS
AU  - PAVLIK, ROMAN
AU  - FRIESE, KLAUS
AU  - SCHOLZ, CHRISTOPH
AU  - JESCHKE, UDO
AU  - DITSCH, NINA
AU  - DIAN, DARIUS
TI  - Expression of Mucin-1, Galectin-1 and Galectin-3 in Human Leiomyosarcoma in Comparison to Leiomyoma and Myometrium
DP  - 2011 Feb 01
TA  - Anticancer Research
PG  - 451--457
VI  - 31
IP  - 2
4099  - http://ar.iiarjournals.org/content/31/2/451.short
4100  - http://ar.iiarjournals.org/content/31/2/451.full
SO  - Anticancer Res2011 Feb 01; 31
AB  - Background: The potential mechanism of malignant transformation from leiomyoma to leiomyosarcoma is still debated. The aim was the evaluation of expression patterns of mucin-1 (MUC1) (MUC1 VU-4-H5), galectin-1 (Gal-1) and galectin-3 (Gal-3) in human myometrium and leiomyoma and in comparison to leiomyosarcoma. Materials and Methods: Myometrium, leiomyoma and leiomyosarcoma tissues were obtained from 79 patients. Samples were analyzed regarding the expression of MUC1, Gal-1 and Gal-3 by immunohistochemical staining of paraffin-embedded material. Results: The expression of MUC1 (VU4-H5) was up-regulated in leiomyoma (p=0.065) and leiomyosarcoma (p=0.039) as compared to the myometrium. In contrast, there were no significant differences in expression of Gal-3 in the tissues from the myometrium, myoma and leiomyosarcoma. Concerning Gal-1 expression, the differences were not significant comparing myometrium and leiomyosarcoma (p=0.277). Myoma had elevated levels of Gal-1 compared to myometrium (p=0.007) and leiomyosarcoma (p<0.0001). Conclusion: MUC1 and Gal-1 might be useful for evaluating the potential of leiomyoma to transform into leiomyosarcoma and, therefore, help in risk-adapted consultation and adjusted treatment.