<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">WEISSENBACHER, TOBIAS</style></author><author><style face="normal" font="default" size="100%">KUHN, CHRISTINA</style></author><author><style face="normal" font="default" size="100%">MAYR, DORIS</style></author><author><style face="normal" font="default" size="100%">PAVLIK, ROMAN</style></author><author><style face="normal" font="default" size="100%">FRIESE, KLAUS</style></author><author><style face="normal" font="default" size="100%">SCHOLZ, CHRISTOPH</style></author><author><style face="normal" font="default" size="100%">JESCHKE, UDO</style></author><author><style face="normal" font="default" size="100%">DITSCH, NINA</style></author><author><style face="normal" font="default" size="100%">DIAN, DARIUS</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of Mucin-1, Galectin-1 and Galectin-3 in Human Leiomyosarcoma in Comparison to Leiomyoma and Myometrium</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011-02-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">451-457</style></pages><volume><style face="normal" font="default" size="100%">31</style></volume><issue><style face="normal" font="default" size="100%">2</style></issue><abstract><style  face="normal" font="default" size="100%">Background: The potential mechanism of malignant transformation from leiomyoma to leiomyosarcoma is still debated. The aim was the evaluation of expression patterns of mucin-1 (MUC1) (MUC1 VU-4-H5), galectin-1 (Gal-1) and galectin-3 (Gal-3) in human myometrium and leiomyoma and in comparison to leiomyosarcoma. Materials and Methods: Myometrium, leiomyoma and leiomyosarcoma tissues were obtained from 79 patients. Samples were analyzed regarding the expression of MUC1, Gal-1 and Gal-3 by immunohistochemical staining of paraffin-embedded material. Results: The expression of MUC1 (VU4-H5) was up-regulated in leiomyoma (p=0.065) and leiomyosarcoma (p=0.039) as compared to the myometrium. In contrast, there were no significant differences in expression of Gal-3 in the tissues from the myometrium, myoma and leiomyosarcoma. Concerning Gal-1 expression, the differences were not significant comparing myometrium and leiomyosarcoma (p=0.277). Myoma had elevated levels of Gal-1 compared to myometrium (p=0.007) and leiomyosarcoma (p&lt;0.0001). Conclusion: MUC1 and Gal-1 might be useful for evaluating the potential of leiomyoma to transform into leiomyosarcoma and, therefore, help in risk-adapted consultation and adjusted treatment.</style></abstract></record></records></xml>