RT Journal Article
SR Electronic
T1 Association of Cyclooxygenase 2 Polymorphic Genotypes with Prostate Cancer in Taiwan
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 221
OP 225
VO 31
IS 1
A1 HSI-CHIN WU
A1 CHAO-HSIANG CHANG
A1 HUNG-LUNG KE
A1 WEN-SHIN CHANG
A1 HUI-NI CHENG
A1 HUI-HUI LIN
A1 CHI-YU WU
A1 CHIA-WEN TSAI
A1 RU-YIN TSAI
A1 WOEI-CHUNG LO
A1 DA-TIAN BAU
YR 2011
UL http://ar.iiarjournals.org/content/31/1/221.abstract
AB The aim of this study was to evaluate the association of polymorphic genotypes in the cyclooxygenase 2 gene (COX2), which is reported to be overexpressed in prostate tumors, with Taiwan prostate cancer patients. Materials and Methods: Six polymorphic variants of COX2 were analyzed for their association with prostate cancer susceptibility. A total of 218 patients with prostate cancer and 436 healthy controls in central Taiwan were enrolled in this investigation. P-values and odds ratios with 95% confidence intervals were used to assess the strength of the association. Results: Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs14133) genotypes were distributed differently between the prostate cancer and control groups. The COX2 −765GG genotype was associated with higher prostate cancer risk than −765GC. Conclusion: These findings provide evidence that the G allele of COX2 promoter G-765C may be associated with the development of prostate cancer and may be a useful marker for early detection of prostate cancer.