RT Journal Article
SR Electronic
T1 Comparison of Microvessel Density Using Nestin and CD34 in Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3889
OP 3895
DO 10.21873/anticanres.12673
VO 38
IS 7
A1 MARIUSZ CHABOWSKI
A1 ALEKSANDRA NOWAK
A1 JEDRZEJ GRZEGRZOLKA
A1 ALEKSANDRA PIOTROWSKA
A1 DARIUSZ JANCZAK
A1 PIOTR DZIEGIEL
YR 2018
UL http://ar.iiarjournals.org/content/38/7/3889.abstract
AB Background/Aim: The aim of the present study was to compare the prognostic value of nestin-positive microvessel density (nestin+ MVD) to the CD34-positive (CD34+) MVD in patients with colorectal cancer. Materials and Methods: A total of 125 cases of colorectal cancer were used for the study. Immunohistochemical reactions were performed on paraffin sections using anti-nestin and anti-CD34. The average MVD was determined for both markers and was referenced to patients' clinicopathological data. Results: A strong positive correlation was found between the MVDs for both analyzed antigens. Contrary to CD34+ MVD, a positive trend was observed between high nestin+ MVD and lymph node invasion. Moreover, significantly higher nestin+ MVD was noted in patients with more advanced clinical stage than in those with early-stage cancer. No such correlation was found for CD34 antigen. Additionally, a possible trend between the higher nestin+ MVD and shorter event-free survival was noted, whereas no such relation was observed for CD34+ MVD. Conclusion: The results suggest that nestin might be a reliable marker for angiogenesis evaluation in patients with colorectal cancer. In contrast to CD34, the expression of nestin in blood vessels seems to be a more sensitive marker of cancer progression.