RT Journal Article SR Electronic T1 Associations Between MTHFR Polymorphisms and the Risk of Potentially Malignant Oral Disorders JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4021 OP 4026 DO 10.21873/anticanres.12690 VO 38 IS 7 A1 THOMAS SENGHORE A1 YU-FENG LI A1 FUNG-CHANG SUNG A1 MING-HSUI TSAI A1 CHUN-HUNG HUA A1 CHIU-SHONG LIU A1 MIN-FENG HUNG A1 CHIH-CHING YEH YR 2018 UL http://ar.iiarjournals.org/content/38/7/4021.abstract AB Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs). Materials and Methods: Genotypes of the MTHFR C677T and A1298C polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: The C677T T allele-carrying genotypes were significantly associated with a decreased risk of PMODs [odds ratio (OR)=0.62, 95% confidence interval (CI)=0.44-0.86]. Haplotype analysis also indicated that the 677T/1298A haplotype was associated with a decreased risk of PMODs (OR=0.56, 95%CI=0.40-0.80). No significant interaction was observed between MTHFR polymorphisms and lifestyle factors. Conclusion: Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples.