RT Journal Article
SR Electronic
T1 Dewaxed Brown Rice Feed Improves Fatty Liver in Obese and Diabetic Model Mice
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4339
OP 4345
DO 10.21873/anticanres.12734
VO 38
IS 7
A1 HIROYUKI INAGAWA
A1 TOSHIYUKI SAIKA
A1 NAOKI NISHIYAMA
A1 TAKASHI NISIZAWA
A1 CHIE KOHCHI
A1 MAYA UENOBE
A1 GEN-ICHIRO SOMA
YR 2018
UL http://ar.iiarjournals.org/content/38/7/4339.abstract
AB Background/Aim: Dewaxed brown rice has macrophage activation ability via TLR4 and contains a high amount of lipopolysaccharides (LPS). It is expected that dewaxed brown rice can help prevent lifestyle diseases. In this study, the anti-obesity effect of dewaxed brown rice was investigated using obese and diabetic model mice. Materials and Methods: Dewaxed brown rice and white rice were polished and powdered by Toyo Rice Co. Diet pellets were prepared (AIN-93) with 50% dewaxed brown rice or white rice powder and fed to type II diabetic model KK-Ay mice for 10 weeks. Weight and fasting blood glucose were measured every week, and whole blood and liver was collected on the final day for the evaluation of biochemical data. Results: A 20% reduction in body weight was found in the dewaxed brown rice feed and white rice feed groups compared to the normal feed group. Fasting blood glucose increased in the normal-diet group, but on the other hand, the blood glucose in the white rice and the dewaxed brown rice feed group was almost constant. Dewaxed brown rice feed group of plasma ALT and AST, liver TG and T-CHO were significantly lower than that of the control and the white rice feed group. Conclusion: Dewaxed brown rice feed has an anti-obesity effect to suppress increasing body weight, fasting blood glucose, and an effect of suppressing fatty liver.