RT Journal Article
SR Electronic
T1 Effect of Combined Epigenetic Treatments and Ectopic NIS Expression on Undifferentiated Thyroid Cancer Cells
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6653
OP 6662
DO 10.21873/anticanres.13032
VO 38
IS 12
A1 MICHELE MASSIMINO
A1 ELENA TIRRÒ
A1 STEFANIA STELLA
A1 FRANCESCO FRASCA
A1 VERONICA VELLA
A1 LAURA SCIACCA
A1 MARIA STELLA PENNISI
A1 SILVIA RITA VITALE
A1 ADRIANA PUMA
A1 CHIARA ROMANO
A1 LIVIA MANZELLA
YR 2018
UL http://ar.iiarjournals.org/content/38/12/6653.abstract
AB Background: Poorly differentiated (PDTC) and anaplastic thyroid (ATC) cancer cells are characterized by the acquisition of epigenetic abnormalities, leading to the silencing of both the sodium iodide co-transporter and the Coxsackie adenovirus receptor. As aberrant histone acetylation and DNA methylation represent epigenetic mechanisms involved in neoplastic transformation, our study investigated the anticancer properties of epigenetic modifiers in thyroid carcinoma. Materials and Methods: The cytotoxicity and gene expression modulation of histone deacetylase and DNA methyltransferase inhibitors were evaluated in both PDTC and ATC. Results: Epigenetic treatments were cytotoxic to tumor thyrocytes and restored sodium iodide co-transporter and Coxsackie adenovirus receptor, expression as well as radioiodine uptake, in PDTC but not in ATC. However, ectopic expression sodium iodide co-transporter re-activated radioiodine incorporation in ATC. Conclusion: The ability of epigenetic treatments to interfere with tumor proliferation and induce Coxsackie adenovirus receptor expression, coupled with the ability of ectopic sodium iodide co-transporter to restore radioiodine uptake, raise the possibility that these therapeutic approaches may provide clinical benefit to patients with thyroid carcinoma refractory to radioiodine treatment.