RT Journal Article
SR Electronic
T1 Correlation Between Disease Stage and the Presence of Viable Circulating Tumor Cells in Endometrial Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2983
OP 2987
VO 38
IS 5
A1 IMRICH KISS
A1 KATARINA KOLOSTOVA
A1 RAFAŁ MATKOWSKI
A1 MARCIN JĘDRYKA
A1 ANDRZEJ CZEKAŃSKI
A1 JIRI PAVLASEK
A1 VLADIMIR BOBEK
YR 2018
UL http://ar.iiarjournals.org/content/38/5/2983.abstract
AB Background/Aim: The presence of circulating tumor cells (CTCs) in the peripheral blood of patients with solid tumors is associated with a poor prognosis. However, there are limited data concerning the detection of CTCs in endometrial cancer (EC). The aim of this study was to evaluate the presence of CTCs in the peripheral blood of patients with EC. Materials and Methods: Peripheral blood samples from 92 patients who underwent a surgical procedure were evaluated using MetaCell® separation technology for CTCs. Results: CTCs were detected in 69 (75%) patients with EC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results showed that the technology applied in this study can efficiently capture viable tumor cells in the blood that can be cultured while maintaining their original phenotype. This paper discusses the first successful culturing of human circulating endometrial cancer cells for further downstream functional and molecular characterization.