PT - JOURNAL ARTICLE AU - IMRICH KISS AU - KATARINA KOLOSTOVA AU - RAFAŁ MATKOWSKI AU - MARCIN JĘDRYKA AU - ANDRZEJ CZEKAŃSKI AU - JIRI PAVLASEK AU - VLADIMIR BOBEK TI - Correlation Between Disease Stage and the Presence of Viable Circulating Tumor Cells in Endometrial Cancer DP - 2018 May 01 TA - Anticancer Research PG - 2983--2987 VI - 38 IP - 5 4099 - http://ar.iiarjournals.org/content/38/5/2983.short 4100 - http://ar.iiarjournals.org/content/38/5/2983.full SO - Anticancer Res2018 May 01; 38 AB - Background/Aim: The presence of circulating tumor cells (CTCs) in the peripheral blood of patients with solid tumors is associated with a poor prognosis. However, there are limited data concerning the detection of CTCs in endometrial cancer (EC). The aim of this study was to evaluate the presence of CTCs in the peripheral blood of patients with EC. Materials and Methods: Peripheral blood samples from 92 patients who underwent a surgical procedure were evaluated using MetaCell® separation technology for CTCs. Results: CTCs were detected in 69 (75%) patients with EC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results showed that the technology applied in this study can efficiently capture viable tumor cells in the blood that can be cultured while maintaining their original phenotype. This paper discusses the first successful culturing of human circulating endometrial cancer cells for further downstream functional and molecular characterization.