RT Journal Article SR Electronic T1 Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6663 OP 6667 DO 10.21873/anticanres.13033 VO 38 IS 12 A1 DONAT PETER SARLOS A1 DANIEL BANYAI A1 LEHEL PETERFI A1 ARPAD SZANTO A1 GYULA KOVACS YR 2018 UL http://ar.iiarjournals.org/content/38/12/6663.abstract AB Background/Aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers. Materials and Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Results: Immunohistochemistry was able to differentiate WT, MA, MTSCC and PRCT. A phenotypic correlation between MA and perilobar nephrogenic rest associated with WT was identified. Conclusion: Perilobar nephrogenic rest and MA arise from differentiation arrested cells of the proximal domain of the S-shape body. We propose that WT1, MA, MTSCC and PRCT derive from different forms of maturation arrested embryonal rests.