TY - JOUR T1 - AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel JF - Anticancer Research JO - Anticancer Res SP - 6699 LP - 6706 DO - 10.21873/anticanres.13038 VL - 38 IS - 12 AU - MASAHIRO YAMAMOTO AU - SHUHEI SUZUKI AU - KEITA TOGASHI AU - TOMOMI SANOMACHI AU - SHIZUKA SEINO AU - CHIFUMI KITANAKA AU - MASASHI OKADA Y1 - 2018/12/01 UR - http://ar.iiarjournals.org/content/38/12/6699.abstract N2 - Background: AS602801, a novel inhibitor of c-Jun N-terminal kinase (JNK), suppresses tumor initiation capacity and metastatic potential of cancer stem cells (CSCs). However, it remains unknown whether this inhibitor can chemosensitize CSCs. Materials and Methods: Using A2780 CSLC, a CSC line derived from ovarian cancer, this study examined the combinational effects of AS602801 and carboplatin or paclitaxel and explored the mechanism of those effects. Results: AS602801 chemosensitized A2780 CSLC cells to carboplatin and paclitaxel. With respect to the mechanism of chemosensitization, the expression of survivin, an anti-apoptotic protein, was reduced by AS602801. Pharmacological and genetic inhibition of survivin chemosensitized the cells to carboplatin and paclitaxel. Suppression of survivin by AS602801 was also observed in other types of CSCs and non-CSCs. Conclusion: AS602801, which reduces survivin expression, can chemosensitize ovarian CSCs and is a candidate drug that targets the chemoresistance, tumor-initiating capacity and metastasis of CSCs. ER -