TY - JOUR T1 - Impact of Osteopenia in Liver Cirrhosis: Special Reference to Standard Bone Mineral Density with Age JF - Anticancer Research JO - Anticancer Res SP - 6465 LP - 6471 DO - 10.21873/anticanres.13009 VL - 38 IS - 11 AU - TAKEO TOSHIMA AU - TOMOHARU YOSHIZUMI AU - TORU IKEGAMI AU - NOBORU HARADA AU - SHINJI ITOH AU - YOHEI MANO AU - TAKASHI MOTOMURA AU - YUJI SOEJIMA AU - YOSHIHIKO MAEHARA Y1 - 2018/11/01 UR - http://ar.iiarjournals.org/content/38/11/6465.abstract N2 - Background/Aim: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD. Patients and Methods: Fifty healthy donors for liver transplantation underwent CT. BMD was measured as cross-sectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD. Results: Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001). Conclusion: Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age. ER -