PT  - JOURNAL ARTICLE
AU  - TAKEO TOSHIMA
AU  - TOMOHARU YOSHIZUMI
AU  - TORU IKEGAMI
AU  - NOBORU HARADA
AU  - SHINJI ITOH
AU  - YOHEI MANO
AU  - TAKASHI MOTOMURA
AU  - YUJI SOEJIMA
AU  - YOSHIHIKO MAEHARA
TI  - Impact of Osteopenia in Liver Cirrhosis: Special Reference to Standard Bone Mineral Density with Age
AID  - 10.21873/anticanres.13009
DP  - 2018 Nov 01
TA  - Anticancer Research
PG  - 6465--6471
VI  - 38
IP  - 11
4099  - http://ar.iiarjournals.org/content/38/11/6465.short
4100  - http://ar.iiarjournals.org/content/38/11/6465.full
SO  - Anticancer Res2018 Nov 01; 38
AB  - Background/Aim: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD. Patients and Methods: Fifty healthy donors for liver transplantation underwent CT. BMD was measured as cross-sectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD. Results: Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001). Conclusion: Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age.