TY - JOUR T1 - Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 6157 LP - 6162 DO - 10.21873/anticanres.12968 VL - 38 IS - 11 AU - SATOMI ARIMOTO AU - TAKUMI HASEGAWA AU - DAISUKE TAKEDA AU - IZUMI SAITO AU - RIKA AMANO AU - MASAYA AKASHI AU - TAKAHIDE KOMORI Y1 - 2018/11/01 UR - http://ar.iiarjournals.org/content/38/11/6157.abstract N2 - Background/Aim: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. Patients and Methods: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. Results: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). Conclusion: Podoplanin and LYVE-1 were strongly associated with LN metastasis. ER -